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KMID : 0361520060170060507
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Korean Journal of Psychopharmacology
2006 Volume.17 No. 6 p.507 ~ p.516
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Association Analysis between P1635 and P1655 Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients
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Park Jin-Soo
Park Byung-Rae
Kim Lyoung-Hyo
Kim Dong-Hyeon
Jang Ho-Joon
Kim Im-Yel
Lee In-Sang
Seo Han-Gil
Lee Cheol-Soon
Kim Bong-Jo
Hahn Kyu-Hee
Jung Han-Yong
Kim Ki-Hoon
Shin Tae-Min
Shin Hyoung-Doo
Woo Sung-Il
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Abstract
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Objective： We investigated the association of P1635 and P1655 polymorphisms on dystrobrevin binding protein 1 (DTNBP1) gene with smooth pursuit eye movement (SPEM) abnormality in Korean schizophrenia patients.
Methods： We measured SPEM function in 216 Korean schizophrenia patients (male 116, female 100) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed P1635 polymorphism and P1655 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups.
Results： The Ln S/N ratio (mean±sd) of the good SPEM function group was 4.39±0.33 and the ratio of poor SPEM function group was 3.18±0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the P1635 polymorphism and P1655 polymorphism on DTNBP1 gene between the two schizophrenia groups divided by SPEM function.
Conclusion：The results suggest that P1635 polymorphism and P1655 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.
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KEYWORD
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Schizophrenia, Dystrobrevin binding protein 1(DTNBP1), P1635, P1655, Smooth pursuit eye movement(SPEM), Genetic polymorphism
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